Table 6.

DE genes putatively activated by NRF2 predicted to be targets of DE miRNAs. Expression of miRNAs is reported for intracellular, extracellular and exosome-like vesicles. NS: Not significant; ND: Not detected.

Upregulated gene ID	Downregulated miRNA	miRNA expression
		Intracellular	Extracellular	Exosome
AKR1C1	ssc-miR-101	NS	Downregulated	Downregulated
AKR1C4	ssc-miR-31	NS	Downregulated	Downregulated
AKR1CL1	ssc-miR-31	NS	Downregulated	Downregulated
BLVRB	prediction_13_40037950_40038026_-_3p-353-MC	NS	ND	Downregulated
EGR1	antisense-ssc-mir-423_12_44150500_44150579_-_NA-353-MC	NS	NS	Downregulated
GCLC	ssc-miR-148b-3p	NS	NS	Downregulated
	ssc-miR-19a	NS	NS	Downregulated
	ssc-miR-19b	NS	NS	Downregulated
GGT1	ssc-miR-338	NS	ND	Downregulated
	ssc-miR-140-3p	NS	NS	Downregulated
	ssc-mir-92-shorter/ssc-isomir-92_X_108178486_108178565_-_NA;ssc-mir- 92-shorter/ssc-isomir-92_X_108212408_108212487_-_NA-424-HC	NS	NS	Downregulated
	ssc-miR-92a	NS	NS	Downregulated
	prediction_7_91732076_91732132_+_5p-353-MC	NS	NS	Downregulated
	ssc-miR-31	NS	Downregulated	Downregulated
	antisense-pn8/bta-mir-2320_6_43886629_43886722_-_NA-424-HC	NS	Downregulated	Downregulated
GSR	ssc-miR-101	NS	Downregulated	Downregulated
	ssc-miR-22-3p	NS	NS	Downregulated
HMOX1	ssc-miR-182	NS	NS	Downregulated
HSP90AB1	ssc-miR-101	NS	Downregulated	Downregulated
NQO1	ssc-miR-34a	NS	NS	Downregulated
PGD	ssc-miR-769-3p	NS	Downregulated	NS
PIR	ssc-miR-378	NS	NS	Downregulated
PRDX1	ssc-miR-101	NS	Downregulated	Downregulated
PRDX6	ssc-miR-10a-5p	NS	NS	Downregulated
	ssc-miR-10b	NS	NS	Downregulated
	ssc-miR-338	NS	ND	Downregulated
SLC5A10	ssc-miR-1307	NS	ND	Downregulated
	antisense-pn8/bta-mir-2320_6_43886629_43886722_-_NA-424-HC	NS	Downregulated	Downregulated
SLC5A6	ssc-miR-10b	NS	NS	Downregulated
	ssc-miR-338	NS	ND	Downregulated
	ssc-miR-423-3p	NS	ND	Downregulated
	ssc-miR-27b-3p	NS	NS	Downregulated
	prediction_7_91732076_91732132_+_5p-353-MC	NS	NS	Downregulated
	ssc-miR-340	NS	ND	Downregulated
SOD2	prediction_7_91732076_91732132_+_5p-353-MC	NS	NS	Downregulated
	ssc-miR-184	Downregulated	ND	ND
	ssc-miR-28-3p	NS	NS	Downregulated
TKT	antisense-ssc-mir-423_12_44150500_44150579_-_NA-353-MC	NS	NS	Downregulated
TXNRD1	ssc-miR-103	NS	NS	Downregulated
	ssc-miR-182	NS	NS	Downregulated
	ssc-mir-107-shorter/ssc-isomir-107_14_106321702_106321788_-_NA-424-HC	NS	Downregulated	Downregulated
	ssc-miR-107	NS	Downregulated	Downregulated
	ssc-miR-31	NS	Downregulated	Downregulated
UGT1A6	ssc-miR-28-3p	NS	NS	Downregulated
	antisense-ssc-mir-103_16_52667657_52667738_+_NA-424-HC	NS	NS	Downregulated
	ssc-miR-769-3p	NS	Downregulated	NS