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. 2020 Aug 13;5:75. doi: 10.1038/s41541-020-00224-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — BALB/c mice (n = 16 per group) were immunized with ChimeraT, rPHB, rEIF5a, rLiHyp1 or rLiHyp2 mixed with saponin adjuvant and, 30 days after the last vaccine dose, serum samples were collected from 8 animals per group. The remaining mice (n = 8 per group) were challenged and, 45 days after infection, their serum samples were also collected. IgG1 and IgG2a isotype antibody levels were measured against the homologous proteins and SLA by an ELISA, a before infection and b after infection. The bars indicate the mean and the error bars denote the standard deviation of the groups. In a (*) indicates significant difference in relation to the control saline and saponin control groups (P < 0.0001). In b (**) indicates statistically significant difference in relation to the recombinant proteins/saponin groups (P < 0.0001). Statistics were done using one-way analysis of variance (ANOVA), followed by Bonferroni´s post-test, which was used for multiple comparisons, and P values < 0.05 were considered significant.