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. 2020 Aug 13;11:4052. doi: 10.1038/s41467-020-17783-4

Fig. 8. Observation of CRET under in vivo mimic conditions.

Fig. 8

a A mixture of ADLumin-1 and CRANAD-3 with Aβ40 aggregates (CRET + Aβ) were injected subcutaneously into the right inner thigh of a female nude mouse and the control group of ADLumin-1+Aβ was injected into the left side; b The mouse was imaged from both the ventral and dorsal sides; c Spectral unmixing was conducted with sequence imaging at 15 min post injection to separate signals from ADLumin-1 (left, green) and from CRET pair (middle, red), and composite image of the two unmixed components (right); D Spectra of the unmixed contributors, ADLumin-1+Aβ (green), and CRET + Aβ (red).