Table 3.
Time effects for plasma oxylipins, with 64 of 67 increasing post-exercise. Oxylipins are categorized by substrate and enzyme systems.
| Substrate | Enzyme | Name | Time effect, FDR |
|---|---|---|---|
| adjusted p-value | |||
| AA | COX | dihomo PGE2 | < 0.001 |
| ALA | LOX | 9-HOTrE | < 0.001 |
| ALA | LOX | 13-HOTrE | < 0.001 |
| ARA | COX | 12-HHTrE | < 0.001 |
| ARA | COX | PGE2 | < 0.001 |
| ARA | COX | TxB2 | < 0.001 |
| ARA | COX | bicyclo PGE2 | 0.833 |
| ARA | COX/Non-enzymatic | PGFM | < 0.001 |
| ARA | CYP | 11,12-EET | < 0.001 |
| ARA | CYP | 11,12-diHETrE | < 0.001 |
| ARA | CYP | 18-HETE | < 0.001 |
| ARA | CYP | 20-HETE | < 0.001 |
| ARA | CYP | 19-HETE | < 0.001 |
| ARA | CYP | 14,15-diHETrE | < 0.001 |
| ARA | CYP | 5,15-diHETE | < 0.001 |
| ARA | CYP | 8,9-diHETrE | < 0.001 |
| ARA | CYP | 5,6-EET | < 0.001 |
| ARA | CYP | 16-HETE | < 0.001 |
| ARA | CYP | 17-HETE | < 0.001 |
| ARA | CYP | 5,6-diHETrE | 0.006 |
| ARA | LOX | 15-HETE | < 0.001 |
| ARA | LOX | 12-HETE | < 0.001 |
| ARA | LOX | tetranor 12-HETE | < 0.001 |
| ARA | LOX | 5-HETE | < 0.001 |
| ARA | LOX | 11-HETE | < 0.001 |
| ARA | LOX | 8-HETE | < 0.001 |
| ARA | LOX | 9-HETE | < 0.001 |
| ARA | LOX | 15R-LXA4 | 0.002 |
| ARA | LOX | 5-oxoETE | 0.007 |
| ARA | LOX | 12-oxoETE | 0.008 |
| ARA | LOX | 6S-LXA4 | 0.428 |
| ARA | Non-enzymatic | 8,12-iso-Isoprostane-F2α-VI | < 0.001 |
| ARA | Non-enzymatic | 13,14-Dihydro-15-keto PGF2a | < 0.001 |
| DGLA | COX | TxB1 | 0.002 |
| DGLA | LOX | 5-HETrE | < 0.001 |
| DGLA | LOX | 15-HETrE | < 0.001 |
| DGLA | LOX | 8-HETrE | < 0.001 |
| DHA | CYP | 20-HDoHE | < 0.001 |
| DHA | CYP | 19,20-DiHDPA | < 0.001 |
| DHA | CYP | 20cooh AA | < 0.001 |
| DHA | LOX | 4-HDoHE | < 0.001 |
| DHA | LOX | 10-HDoHE | < 0.001 |
| DHA | LOX | 16-HDoHE | < 0.001 |
| DHA | LOX | 14-HDoHE | < 0.001 |
| DHA | LOX | 11-HDoHE | < 0.001 |
| DHA | LOX | 13-HDoHE | < 0.001 |
| DHA | LOX | Protectin D1 | < 0.001 |
| DHA | LOX | 17 HDoHE | < 0.001 |
| DHA | LOX | 7-HDoHE | < 0.001 |
| DHA | LOX | 8-HDoHE | 0.003 |
| EPA | COX | TxB3 | < 0.001 |
| EPA | COX | PGE3 | < 0.001 |
| EPA | COX | 18-HEPE | 0.015 |
| EPA | LOX | 12-HEPE | < 0.001 |
| EPA | LOX | 9-HEPE | < 0.001 |
| EPA | LOX | 8-HEPE | < 0.001 |
| EPA | LOX | 5-HEPE | < 0.001 |
| EPA | LOX | 15-HEPE | < 0.001 |
| EPA | LOX | 11-HEPE | < 0.001 |
| EPA | LOX | Resolvin E1 | 0.024 |
| LA | CYP | 12,13-DiHOME | < 0.001 |
| LA | CYP | 9,10-DiHOME | < 0.001 |
| LA | CYP | 9,10-EpOME | 0.851 |
| LA | LOX | 9-HODE | < 0.001 |
| LA | LOX | 13-HODE | < 0.001 |
| LA | LOX | 9-oxoODE | < 0.001 |
| LA | LOX | 13-oxoODE | < 0.001 |
AA, adrenic acid; ALA, alpha-linolenic acid; ARA, arachidonic acid; DGLA, dihomo-gamma-linolenic acid; DHA, docosahexaenoic acid; EPA, Eicosapentaenoic acid; LA, linoleic acid; COX, cyclooxygenase; CYP, cytochrome P450; LOX, lipoxygenase; 20cooh AA, 20-carboxy-arachidonic acid; DiHDPA, dihydroxy-docosapentaenoic acid; DiHETE, dihydroxy-eicosatetraenoic acid; DiHETrE, dihydroxy-eicosatrienoic acid; DiHOME, dihydroxy-9Z-octadecenoic acid; EET, epoxyeicosatrienoic acid; EpOME, epoxyoctadecenoic acid; HDoHE, hydroxy-docosahexaenoic acid; HEPE, hydroxy-eicosapentaenoic acid; HETE, hydroxy-eicosatetraenoic acid; HHTrE, hydroxy-heptadecatrienoic acid; HODE, hydroxy-octadecadienoic acid; HOTrE, hydroxy-octadecatrienoic acid; Lx, lipoxin; oxoETE, oxo-eicosatetraenoic acid; oxo-ODE, oxo-octadecadienoic acid; PG, prostaglandin; TxB, thromboxane.