Table 1.
Androgen receptor expression in mouse and human monocytes and macrophages.
| Species | Cell type | Tissue | Classical AR | Non-classical AR | Quantification method used | Sex differences | References |
|---|---|---|---|---|---|---|---|
| Mouse | Macrophage | Bone-marrow derived | ✓ | ✓ | Flow cytometry Confocal laser scanning microscopy |
M>F | (188) (189) |
| Mouse | Macrophage | Alveolar | ✓ | Flow cytometry | (188) | ||
| Mouse | Macrophage | Liver | ✓ | M>F | (190) | ||
| Mouse | Macrophage | Adipose tissue | ✓ | PCR (KO mouse) | (191) | ||
| Mouse | Macrophage | Skin | ✓ | PCR (KO mouse) Immunocytochemistry |
(192) (186) |
||
| Mouse | Macrophage RAW 264.7 Cell line | Abelson murine leukemia virus-induced tumor; ascites | ✓ | RT-PCR and western blot | (193) | ||
| Mouse | Macrophage | Peritoneal cavity | ✓ | RT-PCR and Western Blot Protein binding assay |
(193) (194) |
||
| Mouse | Macrophage Cell line IC-21 | Peritonealcavity | ✓ | Confocal Laser Scanning Microscopy Flow cytometry |
(195) | ||
| Human | Monocyte derived macrophages | Peripheral blood | ✓ ✓ |
Semi-quantitative PCR Western Blot |
M>F | (196) (197) |
|
| Human | Monocytic cell line, THP-1 (male) | Peripheral blood | ✓ ✓ ✓ |
Western blot RT-PCR |
(198, 199) (193) |
||
| Human | Monocyte | Peripheral blood | ✓ | RT-PCR | (193) | ||
| Human | Macrophage | Synovial tissue | ✓ | Immunohistochemistry; RT-PCR | (200) |