Table 2.

Adverse events (AE): (A) non-immune related; (B) immune related (AST, Aspartate Aminotransferase; ALT, Alanine Aminotransferase).

Adverse event	Grade 1	Grade 2	Grade 3
(A)
Number of patients
Pruritis	5
Diarrhea	5	4
Rash	1	4	1
Fatigue	2	2
Fever	3
Myalgias (leg cramps)	4
Dry skin	1
Hypotension	1		1
Vomiting		1
Increased creatinine		1
Flu like symptoms		1
Elevated AST	1	1
Elevated ALT	1	1
Elevated alkaline phosphatase	1
Colitis			1
Adrenal insufficiency		1
Nausea	1	1
Chills	1
Anorexia		1
Bloating		1
Malaise	1
Hyponatremia	1
Hypokalemia	1
Dupuytren's contracture	1
(B)
Immune-related adverse events	Grade (number of patients if more than 1)
Colitis	3
Maculopapular rash	1,2,3
Diarrhea	1(2), 2
Adrenal insufficiency	2
Pruritis	1
Fever	1
Elevated AST	2
Elevated ALT	2
Elevated alkaline phosphatase	1