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. 2020 Aug 7;10:1289. doi: 10.3389/fonc.2020.01289

Figure 1.

Figure 1

Key events in ubiquitylation and deubiquitylation. A schematic illustration of three-step enzymatic process in ubiquitination. E1, E2, and E3 form a covalent bond to coordinate the editing between ubiquitin and its substrate protein, while DUBs reverse this processing.