Table 1.
Deubiquitinases involved in immune response and T-cell regulation.
| Family | DUB | Function | Target |
|---|---|---|---|
| USP | CYLD | Survival of immature NKT cells | IKK |
| T cell activation | TAK1/IKK | ||
| Thymocyte development | LCK | ||
| Treg development | IKK/Smad7 | ||
| USP4 | TH17 differentiation | RORγt | |
| USP7 | Treg function | Foxp3/ Tip60 | |
| inflammasome activation | NLRP3 | ||
| USP8 | Thymocyte maturation | CHMP5 | |
| USP9X | TCR signaling and central tolerance | Bcl10/Zap70/Themis | |
| USP10 | Unknown | T-bet | |
| USP11 | Immune response | NF-κB pathway | |
| USP15 | T-cell activation and differentiation | MDM2 | |
| TH17 differentiation | RORγt | ||
| USP17 | TH17 differentiation | RORγt | |
| USP18 | TH17 differentiation | RORγt | |
| Innate immune response | IFN-γ pathway | ||
| USP25 | Innate immune response | TLR pathway | |
| USP47 | Inflammasome activation | NLRP3 | |
| OTU | A20 | NKT cell differentiation | MALT1 |
| CD4 T-cell survival | RIPK3 | ||
| T-cell survival | mRORC1 | ||
| CD8 T-cell activation/Treg development/cell-extrinsic regulation of TH1 and TH17 cell differentiation | NF-κB pathway | ||
| DUBA | T-cell activation and differentiation | UBR5 | |
| Otud7b | TH17 differentiation | Zap70 | |
| OTULIN | Innate immune response | NF-κB pathway | |
| BRCC3/ABRO | Inflammasome activation | NLRP3 | |
| Zranb1 | Cell-extrinsic regulation of TH1 and TH17 cell differentiation | Jmjd2b |