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. 2020 Jul 30;36:101662. doi: 10.1016/j.redox.2020.101662

Fig. 1.

Fig. 1

Overexpression of VCP attenuates pressure-overload induced cardiac pathologic remodeling. The morphological alterations after 5 weeks (5 W) transverse aortic constriction (TAC) in both wild type (WT) and VCP transgenic (TG) mice vs sham. A to B. Alterations of aortic systolic and diastolic blood pressure (ASBP and ADBP) measured by invasive catheter in vivo. C. The representative images of echography. D-E: Left ventricular (LV) posterior wall thickness at end-diastole and systole (LVPWd and LVPWs). F-G. LV end diastolic and systolic dimension (LVEDd and LVEDs). H. LV weight normalized by body weights (LVW/BW). I. The representative images and quantitated cross-sectional areas (CSA) of cardiomyocytes in LV tissues. J. The representative images and quantitated collagen density in LV tissue sections. K. The mRNA levels of ANP and BNP normalized with GAPDH. *p < 0.05, **p < 0.01 vs sham; #p < 0.05, ##p < 0.01 vs corresponding WT mice. N = 5 mice/group.