Fig. 2.

Overexpression of the VCP prevents pressure-overload induced cardiac dysfunction. The alterations in cardiac function after 5 weeks (5 W) transverse aortic constriction (TAC) in both wild type (WT) and VCP transgenic (TG) mice vs sham. A-C. LV ejection fraction (EF), fractional shortening (FS), and contractile index in all the groups. D-E: LV end-systolic and -diastolic pressure (LVESP and LVEDP). F-G: The maximum or minimum rate of pressure (+dp/dt) in LV isovolumetric contraction. H. Lung weights normalized by body weights. I. The representative images and quantitated apoptosis ratio measured by histology ex vivo in LV tissues via TUNEL. *p < 0.05, **p < 0.01 vs sham; ^#p < 0.05, ^##p < 0.01 vs corresponding WT mice. N = 5 mice/group.