Fig. 6.

VCP inhibits ROS-associated gene expression and oxidative damages under the TAC. A-C. The mRNA expression of the genes associated with mitochondrial ROS production including the subunits of mitochondrial complexes I (A), III (B) and IV (C). D-F. The representative images and quantitated indicators of ROS-caused oxidative damages in the LV tissues by the immunofluorescent staining (green) of 8-OHdG (D), 4HNE (E) and MDA (F), combining with the Wheat Germ Agglutinin (WGA) staining (red) for cell membrane and DAPI staining (blue) for nucleic acid. *p < 0.05, **p < 0.01 vs sham, ^#p < 0.05 vs corresponding WT mice. N = 3–4/groups. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)