Table 2.
High risk quartile biomarker cutoff values (N = 762).
| System | Biomarker | Cutoff value |
|---|---|---|
| HPA Axis | ||
| Urine cortisol adjusted for creatine (ug/g) | ≤4.40 or≥28.00 | |
| Blood DHEA-S (ug/dL) |
≤30.00 or≥187.00 |
|
| Sympathetic Nervous System | ||
| Urine Epinephrine adjusted for creatine (ug/g) | ≥2.464 | |
| Urine Norepinephrine adjusted for creatine (ug/g) | ≥2.60 | |
| Urine Dopamine adjusted for creatine (ug/g) |
≥182.979 |
|
| Parasympathetic Nervous System | ||
| Heart rate (beats per minute)1 | ≥79.80 | |
| RMSSD | ≤2.49 | |
| SDRR (milliseconds) | ≤3.15 | |
| Low frequency heart rate variability (0.04–0.15 Hz) | ≤4.64 | |
| High frequency heart rate variability (0.15–0.50 Hz) |
≤4.02 |
|
| Inflammatory System | ||
| Serum interleukin-6 (IL6) (pg/mL) | ≥3.47 | |
| Blood C-Reactive protein (ug/mL) | ≥3.66 | |
| Blood fibrinogen (ug/dL) | ≥399.00 | |
| Serum soluble E-Selectin (ng/mL) | ≥51.89 | |
| Serum soluble ICAM-1 (ng/mL) |
≥335.34 |
|
| Cardiovascular System | ||
| Systolic blood pressure2 | ≥143.00 | |
| Diastolic blood pressure2 | ≥82.00 | |
| Pulse pressure3 |
≥64.00 |
|
| Lipid Metabolism | ||
| HDL cholesterol4 | ≤43.00 | |
| LDL cholesterol4 | ≥127.00 | |
| Total to HDL cholesterol4 | ≥4.43 | |
| Triglycerides4 |
≥156.00 |
|
| Glucose Metabolism | ||
| Blood fasting glucose levels mg/dL | ≥105.00 | |
| Blood hemoglobin (HbA1c) percentage | ≥6.242 | |
| Insulin resistance (HOMA-IR) | ≥4.36 | |