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. 2020 Aug 13;40(8):BSR20201427. doi: 10.1042/BSR20201427

Table 5. Detailed information of the seven genes that build the risk scores model.

Official Symbol Official Full Name Biological function
PPARGC1A PPARG coactivator 1 alpha The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism.
P4HA1 prolyl 4-hydroxylase subunit alpha 1 This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits
STC2 stanniocalcin 2 This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions.
ANKZF1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 The expression of this gene in lymph nodes is higher than other tissues, and there is no detailed explanation of biological function.
DLAT dihydrolipoamide S-acetyltransferase This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC).
G6PC2 glucose-6-phosphatase catalytic subunit 2 This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family.
GPC1 glypican 1 Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains.