Table 1.

Factors influencing the efficacy of adjuvant therapies.

Patient/tumor-related	Treatment-related
Tumor histology, grade and stage	Treatment dose
Tumor oxygenation	Extent of body area treated
Mitotic fraction	Method of delivery
Genetic factors	Timing of delivery
Patient comorbidities	Combination of treatment
Medications and allergies	Pervious treatments
Age and performance status	Cumulative toxicity