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. 2020 Aug 7;11:1773. doi: 10.3389/fimmu.2020.01773

Figure 1.

Figure 1

MAIT cells in the lungs of Vα19iTg mice predominantly express the chemokine receptor CXCR6 during F. tularensis LVS intranasal infection. (A) Representative flow cytometry dot plots of MAIT cells in the lungs, spleen (Spl), thymus (Thy), and intestinal lamina propria (LP) of naïve Vα19iTg mice (upper panel) and LVS-infected Vα19iTg mice on day 14 after infection (lower panel). MAIT cells are gated on live 5-OP-RU MR1 tetramer+ TCRβ+ cells in the total cell population for each organ. (B) Representative flow cytometry dot plots depicting expression of different chemokine receptors on MAIT cells in LVS-infected Vα19iTg mouse lungs on day 14 after infection. Plots show live 5-OP-RU MR1 tetramer+ TCRβ+ cells. A graphical representation of the percentage of chemokine receptor-positive MAIT cells in the lungs (C), spleen (D), thymus (E), and intestinal lamina propria (F) in naive and LVS-infected Vα19iTg mice on day 14 after infection (*P < 0.05; **P < 0.01; ***P < 0.001 as compared to naïve mice). Data are presented as the mean ± SEM (n = 4–5) and are representative of two independent experiments.