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. 2020 Aug 13;10:13684. doi: 10.1038/s41598-020-70291-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo results: (A) T₂-weighted MRI of the control (upper, n = 1), SPIO (middle, n = 4), and USPIO (lower, n = 4) animal groups at 0, 7, and 14 days after injection of UC-MSCs. (B) Micrographs of the low-signal-intensity regions observed on MRI at day 14. SPIO and USPIO deposits are demonstrated in the left hemisphere by Prussian-blue staining. Scale bars, 500 μm. UCMSCs umbilical cord-derived mesenchymal stem cells, SPIO superparamagnetic iron oxide, USPIO ultrasmall superparamagnetic iron oxide, MRI magnetic resonance imaging.