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. 2020 Aug 13;11:4043. doi: 10.1038/s41467-020-17725-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, b Effect of a known insulin secretagogues and b diazoxide on the HiBiT peptide secretion (n = 4 technical replicates). IBMX 3-isobutyl-1-methylxanthine. PMA phorbol 12-myristate 13-acetate. c, d Effect of c IBMX and d diazoxide on the IL-10 secretion (n = 3 technical replicates). e Correlation between insulin secretion and IL-10 secretion under varying glucose concentrations (from 1.40 mM to 16.8 mM). Data show means of n = 2 technical replicates. Source data are provided as a Source Data file.