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. 2020 Aug 13;11:4055. doi: 10.1038/s41467-020-17839-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Expression of exogenous TXNIP (top panels) in the PGD^high distant metastasis (38Lg) to levels comparable with baseline TXNIP expression in control PGD^low peritoneal deposit (38Per) removed GLUT1 from the cell surface in PGD^high cells (bottom panels) (n = 3 biological replicates; error bars: s.e.m., indicated p values calculated by two-tailed t tests; G: GFP; TX: TXNIP). Scale bars: 20 µm. b Exogenous TXNIP slowed glucose consumption in the PGD^high cells down to rates comparable with matched PGD^low controls (n = 3 technical replicates, error bars: s.d.m., p < 0.0001 by two-tailed t tests). c Exogenous TXNIP also slowed PGD catalytic rates in PGD^high cells (y-axis: NADPH production rates; n = 3 technical replicates, error bars: s.d.m., p = 0.003 by two-tailed t tests). d Exogenous TXNIP strongly impaired 3D tumoroid growth of PGD^high cells with no effect on control PGD^low contro^ls (n = 3–12 technical replicates; error bars: s.d.m., indicated p values calculated by two-tailed t tests). Top panels: brightfield microscopy of live tumoroids. Bottom panels: H&E stains of fixed tumoroids. Scale bars: 400 µm.