Table 2.
Evolution of systemic hemodynamics, respiratory, and biological variables over time in septic shock (n = 7) animals
| Variables | Time point 0SS | Time point 1SS | Time point 2SS | Time point 3SS | Time point 4SS | Time point 5SS | Friedman (p) |
|---|---|---|---|---|---|---|---|
| Noradrenaline | Off | On | On | On | On | Off | NA |
| T (°C) | 39.3 (38.1–40.3) | 39.3 (38.7–40.3) | 40.0 (39.6–40.7) | 40.7 (40.7–40.8) | 40.6 (40.1–40.8) | 40.0 (39.7–41.0) | < 0.001 |
| CI (l/min/m2) | 1.7 (1.5–2.3) | 2.2. (1.8–2.4) | 2.2 (2.2–4.0) | 2.3 (2.3–3.7) | 1.4 (1.0–2.6) | 1.1 (0.7–2.4) | 0.11 |
| MAP (mmHg) | 78 (72–80) | 79 (75–81) | 78 (77–83) | 78 (77–80) | 73 (71–79) | 51 (48–55)b,c,d | 0.009 |
| MPAP (mmHg) | 15 (11–17) | 19 (17–23) | 26 (21–29) | 29 (24–33) | 29 (26–32)b | 30 (26–35) | < 0.001 |
| PaO2/FiO2 | 383 (327–399) | 340 (310–378) | 288 (226–302) | 235 (175–292) | 175 (159–223) | 166 (135–199) | 0.05 |
| PaCO2 (mmHg) | 35 (34–35) | 35 (33–38) | 37 (34–43) | 37 (36–40) | 39 (38–41) | 38 (30–39) | 0.05 |
| PaO2 (mmHg) | 114 (108–123) | 104 (98–113) | 91 (83–97) | 105 (97–112) | 106 (98–122) | 104 (97–120) | 0.31 |
| Hb (g/dl) | 8.7 (7.7–9.6) | 9.7 (7.2–11.2) | 9.9 (8–10.4) | 9.6 (8.2–10.1) | 7.4 (6.2–9.1) | 5.5 (4.9–7.8) | 0.003 |
| Lactate (mmol/l) | 1.4 (0.9–1.8) | 1.6 (1.0–2.4) | 2.3 (1.9–2.7) | 4.8 (3.6–5.8) | 6.4 (6–10) | 8.7 (8.7–10.3)a,b,c,d | < 0.001 |
| pH | 7.38 (7.37–7.46) | 7.36 (7.34–7.38) | 7.26 (7.23–7.33) | 7.12 (7.04–7.28) | 6.9 (6.81–7.17) | 6.9 (6.77–7.02)c,d | < 0.001 |
| Midazolam(mg/kg) | 29 (25–40) | 36 (30–43) | 44 (43–49) | 57 (53–59) | 59 (57–68) | 60 (57–70) | < 0.001 |
| Ketamine (mg/kg) | 194 (164–265) | 237 (201–290) | 296 (284–329) | 378 (352–395) | 396 (383–453) | 401 (383–467) | < 0.001 |
Data are presented as median and (IQR). Only significant post-hoc analysis is presented; the corresponding ANOVA p values are bold. Significant at 5% vs (a) time point 0SS, (b) time point 1SS, (c) time point 2SS, and (d) time point 3SS in the within-group analysis
°C Celsius degrees, CI cardiac index, MAP mean arterial pressure, MPAP mean pulmonary arterial pressure, PaO2/FiO2 ratio used to identify and quantify acute lung injury (acute lung injury if ratio ≤ 300, acute respiratory distress syndrome if ratio ≤ 200), Hb hemoglobin, SS septic shock