Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 13;11:4057. doi: 10.1038/s41467-020-17902-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 8 — a (Top) Comparison of z-scored, trial-averaged M1 cross-area activity magnitudes during baseline (yellow) and M2 inactivation (gray) for one example animal. M1 CCA weights were defined during baseline period and used to calculate cross-area activity during both baseline and M2 inactivation trials. Solid line shows mean and shaded region shows standard error of the mean. (Bottom) As above, but for M1 local signals during baseline (red) and M2 inactivation (gray), suggesting that local signals are not as impacted by M2 inactivation. n = 91 trials for Baseline, n = 92 trials for M2 Muscimol. b Probability density function of M1 cross-area neural activity during baseline trials. Pre-reach activity in black. Reach start activity in gray. c As in b, but during M2 inactivation trials. d Quantification of (b, c) as the difference between median pre-reach and reach activity during baseline and M2 inactivation trials in M1 cross-area subspace. Yellow lines show data from individual animals, black line shows mean ± SEM, n = 3 rats. p = 0.02. *p < 0.05. two-sided t-statistic, not adjusted for multiple comparisons. e Detection of reach initiation from M1 cross-area subspace activity using ROC analysis on logistic regression model (example animal). (Inset) Difference in reach detection quantified as the area under the curve (AOC) for all animals. Gray lines show data from individual animals; black lines show mean ± SEM, n = 3 rats. p = 0.02. *p < 0.05. two-sided t-statistic, not adjusted for multiple comparisons. f M1 cross-area activity (CA) modulation decreases significantly with M2 inactivation. Yellow lines, also marked with black open circles, show data from individual animals, bars show mean ± std dev., n = 3 rats. ****p < 0.0001. One-sided hierarchical bootstrap, not adjusted for multiple comparisons. g Single-trial M1 CA-modulation predicts single-trial reach duration even during M2 inactivation. Plot shows random subsampling of trials across animals, all trials were used in quantification.