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. 2020 Aug 13;9(8):72. doi: 10.1038/s41389-020-00257-z

Fig. 6. Synergistic efficacy of irradiation and PD-L1-CAR T-cell therapy in a PD-L1 low NSCLC xenograft model.

Fig. 6

a Experimental design of tumor cell xenograft model treated with CAR T cells and/or irradiation. b Serial bioluminescence imaging of tumor progression and regression in each group (n = 3 mice per group). c Bioluminescence kinetics of A549-Fluc (n = 3 mice per group) in each treatment group. d Representative IHC of PD-L1 in irradiation-treated NSCLC tumors. Scale bars, 100 µm. e Representative images of CD3 IHC in PD-L1-CAR T cell-treated and irradiation-treated NSCLC tumors. Scale bars, 100 µm. f Hematoxylin and eosin staining of tumors. Scale bars, 50 µm. *p ≤ 0.05.