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. 2020 Aug 13;10:13671. doi: 10.1038/s41598-020-70689-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The oral administration of the medium-dose of Ga decreases BW gain without reducing food intake in obese mice. BW gain (2-1) and cumulative food intake (2-2) were measured (n = 8 in each group). VO2 values (2-3), locomotor activities during light and dark phases (2-4) and rectal temperature (2-5) were estimated (n = 7 in each group). Leprb expression (2-6, n = 8) and the pAMPK/AMPK ratio (2-7, n = 4) in livers were determined. White column and black column represent the saline-treated group and the Ga-treated group, respectively. Data are presented as the mean ± SEM. *P < 0.05 and **P < 0.01 compared to the saline-treated group, respectively.