Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 24;32(13):982–992. doi: 10.1089/ars.2020.8027

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Eunice E. To et al., 2020; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

FIG. 3. — Schematic representation of the endosomal ROS production pathway to virus infection. Viruses that internalize via endocytosis are sensed by endosomally located TLRs, in particular TLR7 for ssRNA viruses and TLR9 for DNA viruses (for clarity, endosome TLR3 is not shown). Activation of TLR7-MyD88 mediates ROS generation via PKC, which triggers the phosphorylation of specific serine residues on the p47^phox subunit that promotes the assembly of a functional NOX2 oxidase enzyme. The H₂O₂ generated within endosomal compartments by NOX2 targets cysteine 98 (C98) on the ectodomain of TLR7. PKC, protein kinase C; TLR, toll-like receptor. Color images are available online.