Figure 7.
The BRG1 inhibitor PFI-3 sensitizes GICs to chemotherapy. (A): X16 GICs were treated with TMZ (500 μM) and PFI-3 (1 μM), and cell proliferation was determined by CellTiter-Glo assays. (B): Protein lysates from X16 GICs treated with PFI-3 were immunoblotted for GFAP and actin. (C): X10 GICs were treated with TMZ (500 μM) and PFI-3 (1 μM), and cell proliferation was determined by CellTiter-Glo assays. (D): X10 and X16 GICs were treated with carmustine (10 μM) and PFI-3 (1 μM), and CellTiter-Glo assays performed. *p ≤ .05 was considered to be statistically significant.