TABLE 2.
Univariate and multivariate analyses of prognostic factors associated with overall survival of HCC patients
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Variable | P value | HR (95% CI) | P value | HR (95% CI) |
| Gender (female vs. male) | 0.543 | 1.241 (0.619‐2.491) | ||
| Age (> 50 vs. ≤50 years) | 0.303 | 1.270 (0.806‐2.000) | ||
| AFP level (> 400 vs. ≤400 ng/mL) | 0.197 | 1.347 (0.857‐2.119) | ||
| HBV infection (yes vs. no) | 0.826 | 0.928 (0.477‐1.805) | ||
| Tumor number (multiple vs. single) | <0.001 | 4.319 (2.734‐6.822) | <0.001 | 4.174 (2.586‐6.738) |
| Tumor size (> 5 vs. ≤5 cm) | <0.001 | 3.157 (1.817‐5.485) | 0.016 | 2.028 (1.138‐3.614) |
| Serum ALT (> 40 vs. ≤40 U/L) | 0.244 | 1.308 (0.833‐2.054) | ||
| Serum AST (> 40 vs. ≤40 U/L) | 0.049 | 1.575 (1.003‐2.474) | 0.135 | 1.439 (0.893‐2.317) |
| Albumin (> 35 vs. ≤35 g/L) | <0.001 | 0.886 (0.833‐0.943) | 0.001 | 0.897 (0.842‐0.955) |
| Total bilirubin (> 21 vs. ≤21 μmol/L) | 0.092 | 1.673 (0.920‐3.041) | ||
| Prothrombin time (> 13.5 vs. ≤13.5 s) | 0.502 | 1.199 (0.705‐2.039) | ||
| Macrovascular invasion (yes vs. no) | 0.005 | 2.863 (1.368‐5.995) | 0.120 | 1.827 (0.855‐3.902) |
| Differentiation grade (III+IV vs. I+II) | 0.166 | 1.375 (0.876‐2.157) | ||
| Cirrhosis (yes vs. no) | 0.347 | 1.244 (0.790‐1.959) | ||
| TESC level (high vs. low) | 0.018 | 1.729 (1.100‐2.719) | 0.011 | 1.863 (1.155‐3.005) |
HCC: hepatocellular carcinoma; HR: hazard ratio; CI: confidence interval; HBV: hepatitis B virus; AFP: alpha‐fetoprotein; ALT: alanine aminotransferase; AST: aspartate aminotransferase; TESC: Tescalcin.