Supplemental Table 13.
Variance–Covariance Matrix Base Case Cost Regression Analysis
| Variable | Tumor Grade |
HR | Year |
#Year |
Progression | Progression History | TCC History | Gender | Diabetes | Celecoxib | Toxicity |
#Toxicity |
Age, y |
BMI |
Smoking |
Constant |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Unknown | 1 | 2 | 3 | 2 | 3 | 2 | 3 | Mild | Moderate | Mild | Moderate | 50-60 | 60-70 | 70-80 | >80 | Overweight | Obese | Morbidly Obese | Previous | Current | |||||||||
| Tumor grade | |||||||||||||||||||||||||||||
| Unknown | 2989584 | ||||||||||||||||||||||||||||
| 1 | 3197.897 | 173025.4 | |||||||||||||||||||||||||||
| 2 | 455.0007 | 5153.004 | 148982.9 | ||||||||||||||||||||||||||
| 3 | 4751.888 | 1440.31 | 5766.639 | 687863.1 | |||||||||||||||||||||||||
| HR | −12,708.1 | 7947.394 | 6233.751 | −12,978.7 | 97,028.53 | ||||||||||||||||||||||||
| Year | |||||||||||||||||||||||||||||
| 2 | 128.5532 | 2513.226 | 5118.316 | 2360.683 | 45,236.91 | 63,355.2 | |||||||||||||||||||||||
| 3 | 417.7922 | 6185.773 | 9399.375 | 3398.295 | 46,386.92 | 47,142.29 | 54,752.65 | ||||||||||||||||||||||
| HR # year 2 | 12,903.19 | −2631.28 | −1898.03 | 13,670.3 | −92,607.2 | −61,490.2 | −44,871.9 | 118204.4 | |||||||||||||||||||||
| HR # year 3 | 10,099.37 | −5412.12 | −5798.32 | 12,242.9 | −94,413.4 | −44,807.9 | −51,859.6 | 91,808.03 | 102383.7 | ||||||||||||||||||||
| Progression | 3772.371 | 67.20135 | −12,774.8 | −87,906.4 | −11,840.8 | −1096.95 | −1184.22 | 6543.22 | 10,696.11 | 1,960,938 | |||||||||||||||||||
| Progression history | 3597.378 | 131.9645 | 1131.308 | 3651.328 | −756.922 | 429.5359 | 37.94244 | −3169.66 | −1512.31 | 47,298.56 | 651011.4 | ||||||||||||||||||
| TCC history | −3973.36 | 177.3514 | −249.955 | −618.622 | 1794.413 | 201.794 | 446.6992 | −80.3491 | −176.578 | −1414.4 | −2551.17 | 8372.969 | |||||||||||||||||
| Patient gender | −2929.97 | −77.8528 | 500.8079 | 550.0644 | −184.652 | 924.8961 | 1028.345 | −228.396 | −256.491 | −934.697 | −1450.44 | 634.9075 | 10,888.51 | ||||||||||||||||
| Diabetes | 174.1897 | 458.7002 | −786.564 | −1579.5 | 61.53177 | 93.05056 | −59.2129 | −127.267 | −313.961 | 1281.531 | −1474.4 | 518.0848 | 588.3711 | 21,619.53 | |||||||||||||||
| Celecoxib | 2048.935 | 402.4205 | −98.0007 | 920.2471 | 216.8488 | −36.8882 | −714.756 | 81.53749 | 647.6306 | 231.6324 | 515.0038 | −10.0378 | −759.794 | −1101.22 | 8200.721 | ||||||||||||||
| Toxicity | |||||||||||||||||||||||||||||
| Mild | −600.194 | 429.0679 | 321.6055 | −73.1877 | 630.1364 | 4588.025 | 5054.176 | −527.603 | −608.46 | 713.4595 | 1786.313 | 298.7808 | 2207.895 | −454.888 | 3779.813 | 30,199.89 | |||||||||||||
| Moderate | 2383.184 | −2263.53 | 1663.632 | 2924.52 | −1789.75 | 6931.381 | 6671.093 | 103.2672 | 3430.716 | 4155.016 | 1639.651 | 135.8265 | 1061.755 | −97.2649 | 3874.048 | 6976.896 | 90,355.71 | ||||||||||||
| Celecoxib # mild | 438.1648 | −1952.97 | 601.5322 | −1065.34 | −393.143 | −880.25 | 427.7197 | −287.85 | −203.163 | −1276.02 | −266.424 | 226.7488 | −1008.46 | 427.0523 | −7417.36 | −29,182.4 | −5234.27 | 58,706.88 | |||||||||||
| Celecoxib # moderate | −578.645 | 204.5142 | −1252.18 | −3234.89 | 3614.205 | −463.231 | 1200.66 | −1325.14 | −5724.77 | −4619.99 | −150.712 | −435.541 | −60.541 | 550.1123 | −7471.91 | −5457.64 | −88,242.4 | 9219.409 | 150368.5 | ||||||||||
| Age, y | |||||||||||||||||||||||||||||
| 50-60 | −461.326 | −1297.4 | −2167.35 | −219.887 | 877.5002 | −383.189 | −780.626 | −62.6462 | 536.8991 | 1446.35 | −632.307 | 54.15569 | −388.29 | −844.322 | 1911.414 | −315.633 | −16.8047 | −1357.87 | −284.003 | 37,575.4 | |||||||||
| 60-70 | −760.247 | −565.579 | −1189.19 | −1265.14 | 1569.057 | −532.382 | −836.337 | 80.84493 | 565.3626 | −535.485 | −3198.85 | 294.7149 | −1511.36 | −2402.45 | 2058.851 | −920.176 | −519.123 | −1076.13 | −61.9788 | 27,048.9 | 31,468.3 | ||||||||
| 70-80 | −3417.03 | −643.19 | −422.365 | −493.563 | 1144.489 | −680.322 | −1062.53 | 32.89036 | 515.9473 | −632.644 | −2133.45 | −233.831 | −1363.8 | −2793.31 | 1804.646 | −1484.46 | −1129.18 | 375.9521 | −995.23 | 26,940.94 | 27,342.93 | 33,316.37 | |||||||
| >80 | −2210.66 | −1113.08 | −169.061 | −1806.11 | 892.5153 | −297.992 | −451.897 | 16.11853 | 386.4642 | 1645.557 | −342.335 | 140.223 | −925.094 | −1278.83 | 2066.425 | −156.349 | 460.59 | −827.155 | −2429.76 | 27,010.24 | 27,247.6 | 27,388.06 | 51,528.18 | ||||||
| BMI | |||||||||||||||||||||||||||||
| Overweight | 3529.466 | 573.0519 | −339.4 | −552.401 | 250.3219 | 24.09107 | 739.0862 | 109.069 | −443.283 | 491.4164 | 290.0057 | −150.674 | −73.1737 | −792.842 | −161.863 | 724.8933 | −623.956 | −1356.18 | 1204.683 | −556.359 | −313.425 | 38.44737 | −1558.25 | 9173.863 | |||||
| Obese | 3521.786 | 400.006 | −595.534 | −726.146 | −612.32 | −32.3199 | 604.3832 | 90.40263 | −260.271 | −246.015 | 1816.794 | −373.677 | −373.834 | −3086.28 | −306.06 | 117.209 | −1073.1 | 28.07319 | 1280.047 | −2138.66 | −816.066 | 193.7971 | −609.137 | 5204.197 | 12,842.01 | ||||
| Morbidly obese | −118.211 | −9986.43 | −9469.14 | −2409.75 | −2017.09 | 40.76192 | 1044.331 | 456.362 | 986.1302 | 3133.209 | 1577.672 | 33.32034 | 4273.654 | −6030.72 | −2071.96 | 2339.3 | 19.31831 | −1655.31 | 1015.499 | 4159.043 | 3032.126 | 6170.16 | 5360.11 | 5745.526 | 6500.394 | 388509.5 | |||
| Smoking | |||||||||||||||||||||||||||||
| Previous | 3051.792 | −192.533 | −525.105 | 735.3619 | 147.8917 | −410.739 | −357.737 | 167.0641 | −65.6603 | −492.734 | 1603.186 | −316.844 | −1847.56 | −829.911 | 91.54407 | −1454.3 | −945.744 | 1053.433 | −61.0395 | −905.897 | −1423.65 | −677.65 | −1246.05 | −968.874 | -696.796 | −4306.3 | 9446.943 | ||
| Current | 3021.291 | 1286.492 | −351.976 | 619.1337 | 1659.942 | −449.125 | −294.024 | 231.7881 | −115.202 | −93.4865 | 785.4893 | 216.0982 | −2526.05 | −1053.26 | −581.953 | −978.082 | −1439.44 | 1179.949 | 787.8671 | 1593.945 | 1184.458 | 2831.625 | 2421.957 | 409.944 | 639.0463 | −575.662 | 5894.281 | 14,982.78 | |
| Constant | −650.554 | −8561.44 | −9019.26 | −3331.26 | −50,134.5 | −48,152.1 | −49,973.6 | 45,313.96 | 46,188.36 | 2439.925 | 2001.973 | −4320.44 | −6659.01 | 1944.855 | −5262.25 | −9175.75 | −10,217.5 | 5459.517 | 3663.643 | −26,755.5 | −26,623.3 | −26,969.7 | −26,842.4 | −4592.3 | −3397.78 | −9238.54 | −2227.81 | −6309.84 | 93,066.23 |
Abbreviations: BMI = body mass index; CI = confidence interval; ECG = electrocardiography; HR = high risk; HRQoL = health-related quality of life; SE = standard error; TCC = transitional cell carcinoma.