Figure 5.

Clonal Structure of the IBD Colon

(A) For pairs of crypts from the same biopsy, the figure shows the number of mutations that are shared between a pair as a fraction of the average mutation burden of the two crypts, and this is plotted as a function of the distance between the pair.

(B) A phylogenetic tree showing crypts sampled from 9 biopsies from the sigmoid colon of a 36-year-old male diagnosed with Crohn’s disease 19 years prior to sampling. Biopsies were taken 1 cm apart in a three by three grid for all the patients in (B)-(D).

(C) A phylogenetic tree showing crypts sampled from 9 biopsies from the rectum of a 71-year-old male diagnosed with ulcerative colitis 4 years prior to sampling.

(D) A phylogenetic tree showing crypts sampled from 9 biopsies from the rectum of a 42-year-old female diagnosed with ulcerative colitis 13 years prior to sampling.

See also Figures S3 and S4.