Table 4.
Changes in CRP Seen in the Ciprofloxacin and Placebo Groups at Study Visits
| Visit 1 (72 Placebo/71 Ciprofloxacin) | Visit 2 (65 Placebo/66 Ciprofloxacin) | Visit 3 (64 Placebo/63 Ciprofloxacin) | Visit 4 (63 Placebo/63 Ciprofloxacin) | |
|---|---|---|---|---|
| CRP placebo | 15.1 (17.2) | 11.0 (17.2) | 9.8 (17.7) | 9.0 (15.2) |
| CRP ciprofloxacin | 10.9 (12.3) | 9.8 (13.1) | 7.0 (17.7) | 15.2 (46.9) |
| As change from baseline | — | 63 placebo/66 ciprofloxacin | 62 placebo/62 ciprofloxacin | 61 placebo/62 ciprofloxacin |
| CRP placebo | — | −5.1 (22.1) | −5.3 (17.0) | −6.4 (20.1) |
| CRP ciprofloxacin | — | −1.7 (14.7) | −4.6 (12.4) | 3.9 (48.0) |
| P value, t test | — | 0.310 | 0.815 | 0.124 |
| Median (IQR) | ||||
| CRP placebo | — | −2 (−13 to 0) | −1.75 (−9 to 0.1) | −2 (−11.5 to 1) |
| CRP ciprofloxacin | — | 0 (−5 to 2) | −1 (−5 to 1) | −1 (−4 to 0) |
| P value, Mann-Whitney test | — | 0.030 | 0.741 | 0.195 |
Definition of abbreviations: CRP = C-reactive protein; IQR = interquartile range.
Data are shown as mean (SD) unless otherwise noted.