Figure 4.

Diagnostic RNA model and survival in pulmonary arterial hypertension (PAH). (A) Box plot of LASSO model score in control subjects and patients with PAH separated by survival status during follow-up. Dashed line shows the cutoff that identified 88.9% of nonsurviving patients with PAH. (B) Kaplan-Meier survival plot separating patients on the basis of the 88.9% sensitive cutoff. (C) Box plot of RNA model score in healthy volunteers and patients with PAH divided by WHO functional class. (D) Box plot of RNA model score in patients with PAH divided by presence of low, intermediate, or high levels of cardiac biomarkers BNP (brain natriuretic peptide) (<50, 50–300, or >300 pg/ml) or NT-proBNP (N-terminal pro-brain natriuretic peptide) (<300, 300–1,400, or >1,400 pg/ml), as per European guidelines for PAH assessment. LASSO = least absolute shrinkage and selection operator; WHO = World Health Organization.