Table 3.
Univariable Associations between Covariates of Interest and Time to First AR Event in the First Year after Lung Transplantation
| Covariate of Interest | Effect Estimate [HR (95% CI)] | P Value |
|---|---|---|
| Time-independent covariates | ||
| Age at transplant, ≥65 yr vs. <65 yr | 1.13 (0.84–1.53) | 0.41 |
| Sex, F vs. M | 0.77 (0.58–1.02) | 0.06 |
| UNOS native lung disease category | ||
| B vs. A | 0.61 (0.25–1.53) | 0.29 |
| C vs. A | 1.20 (0.76–1.89) | 0.44 |
| D vs. A | 1.23 (0.90–1.69) | 0.19 |
| Transplant type, bilateral vs. single | 0.56 (0.41–0.76) | <0.01 |
| LAS at transplant, continuous, per 10 points | 0.99 (0.90–1.08) | 0.82 |
| Induction immunosuppression, yes vs. no | 0.59 (0.30–1.18) | 0.13 |
| Maintenance immunosuppression, cyclosporine vs. tacrolimus | 1.07 (0.63–1.85) | 0.80 |
| Donor age, continuous, per 5 yr | 0.95 (0.91–0.99) | 0.03 |
| Donor race | ||
| Other vs. African American | 1.35 (0.83–2.20) | 0.22 |
| White vs. African American | 1.27 (0.86–1.87) | 0.23 |
| Donor sex, F vs. M | 0.97 (0.73–1.27) | 0.81 |
| Donor cause of death, ICH/blunt injury vs. other | 1.01 (0.76–1.33) | 0.96 |
| Ischemic time, continuous, h | 1.01 (0.96–1.05) | 0.81 |
| Total HLA mismatch, 4–6 vs. 0–3 | 2.10 (1.34–3.31) | <0.01 |
| HLA A mismatch, 2 vs. 0–1 | 1.13 (0.86–1.48) | 0.37 |
| HLA B mismatch, 2 vs. 0–1 | 1.15 (0.85–1.55) | 0.36 |
| HLA DR mismatch, 2 vs. 0–1 | 1.33 (1.01–1.75) | 0.04 |
| HLA A/B mismatch | ||
| 2 vs. 0–1 | 0.86 (0.39–1.89) | 0.71 |
| 3 vs. 0–1 | 1.27 (0.62–2.62) | 0.52 |
| 4 vs. 0–1 | 1.14 0.55–2.36) | 0.73 |
| HLA A/DR mismatch | ||
| 2 vs. 0–1 | 1.95 (0.84–4.56) | 0.12 |
| 3 vs. 0–1 | 1.82 (0.79–4.18) | 0.16 |
| 4 vs. 0–1 | 2.33 (1.01–5.37) | 0.05 |
| Recipient HLA-sensitized pretransplant, yes vs. no | 1.01 (0.76–1.35) | 0.94 |
| pTLC ratio, continuous | 0.58 (0.24–1.38) | 0.22 |
| Recipient/donor sex mismatch | ||
| F/M vs. matched | 0.74 (0.48–1.15) | 0.18 |
| M/F vs. matched | 1.12 (0.78–1.63) | 0.54 |
| PGD grade 3 within 72 h, yes vs. no | 0.74 (0.50–1.08) | 0.11 |
| Time-dependent covariates | ||
| Any bacterial infection, yes vs. no | 1.16 (0.86–1.56) | 0.35 |
| Any fungal infection, yes vs. no | 1.11 (0.75–1.63) | 0.61 |
| Any viral infection, yes vs. no | 1.10 (0.76–1.59) | 0.62 |
| Any mycobacterial infection, yes vs. no | 1.14 (0.69–1.86) | 0.61 |
| Any CMV, yes vs. no | 1.09 (0.54–2.21) | 0.81 |
| Any augmented immunosuppression, yes vs. no | 0.87 (0.61–1.24) | 0.43 |
Definition of abbreviations: AR = acute perivascular rejection; CI = confidence interval; CMV = cytomegalovirus; HR = hazard ratio; ICH = intracranial hemorrhage; LAS = lung allocation score; PGD = primary graft dysfunction; pTLC ratio = donor to recipient predicted TLC ratio; UNOS = United Network for Organ Sharing; UNOS native lung disease category A = obstructive lung disease; UNOS native lung disease category B = pulmonary vascular disease; UNOS native lung disease category C = cystic fibrosis; UNOS native lung disease category D = restrictive lung disease.
Enrolling center is included in the model as a random effect.