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. 2020 Aug 7;11:1197. doi: 10.3389/fphar.2020.01197

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Copyright © 2020 Yi, Xu, Huang, Zhang, Qing, Li, Wang, Zeng, Lu and Han

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TPPU decreased brain edema and BBB permeability in rat pMCAO model. (A) Percentage of brain edema content in the ischemic hemisphere (n = 6 for each group). (B) Evans blue dye leakage (n = 6 for each group). ^# P < 0.01 vs. the sham group; *P < 0.05, **P < 0.01 vs. the pMCAO group. pMCAO, permanent middle cerebral artery occlusion; TPPU, 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea; BBB, blood-brain barrier.