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. 2020 Aug 7;11:1197. doi: 10.3389/fphar.2020.01197

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Copyright © 2020 Yi, Xu, Huang, Zhang, Qing, Li, Wang, Zeng, Lu and Han

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TPPU inhibited the OGD/R-Induced ROS generation and levels of inflammatory cytokines. (A) Representative micrographs of ROS generation (under fluorescence microscope). Scale bar = 100 μm. (B, C) ROS generation measured by flow cytometry (n = 6). Effects of TPPU treatment on IL-1β (D), IL-6 (E), TNF-α (F) (n = 6). ^# P < 0.01 vs. control group; *P < 0.05, **P < 0.01 vs. OGD/R group. OGD/R, oxygen-glucose deprivation/reperfusion; TPPU, 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea; ROS, reactive oxygen species; HBMVECs, human brain microvascular endothelial cells; IL-1β, interleukin-1β; IL-6, Interleukin-6; TNF-α, tumor necrosis factor-α.