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. Author manuscript; available in PMC: 2021 May 23.
Published in final edited form as: Best Pract Res Clin Endocrinol Metab. 2020 May 23;34(3):101428. doi: 10.1016/j.beem.2020.101428

Figure 1. Gene-based diagnostic algorithm for primary cortisol-producing adrenocortical hyperplasias.

Figure 1.

Abbreviations: APC, adenomatous polyposis coligene; ARMC5, armadillo repeat-containing protein 5; c-PPNAD, CNC-associated primary pigmented nodular adrenocortical disease; FH, fumarate hydratase; GNAS, gene coding for the stimulatory subunit α of the G-protein (Gsα); i-MAD, isolated micronodular adrenocortical disease; i-PPNAD, isolated PPNAD; MAS, McCune–Albright syndrome; MEN1, multiple endocrine neoplasia type 1; PBAD, primary bimorphic adrenocortical disease; PBMAH, primary bilateral macronodular adrenocortical hyperplasia; PDE8B, phosphodiesterase 8B gene; PDE11A, phosphodiesterase 11A gene PPNAD, primary pigmented nodular adrenocortical disease; PRKACA, protein kinase, cAMP-dependent, catalytic, alpha; PRKAR1A, protein kinase, cAMP-dependent, regulatory, type I, α gene.