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. 2020 Aug 7;11:1211. doi: 10.3389/fphar.2020.01211

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Copyright © 2020 Zhang, Liu, Li, Liu, Zhuang, Feng, Yao and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antiinvasive effect of podophyllotoxin. In vitro invasion assay was used to observe the invasion of drugs on triple negative breast cancer cells (MDA-MB-231, MDA-MB-468). (A) After 24 h of intervention with podophyllotoxin, we found that the number of cells passing through the chamber decreased significantly, and podophyllotoxin could inhibit the invasion of triple negative breast cancer. (B) Bar graphs show the quantitative expression of by the number of invasive cells in transwell experiment. *p < 0.05 is considered statistically significant.