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. 2020 Aug 7;11:1211. doi: 10.3389/fphar.2020.01211

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Copyright © 2020 Zhang, Liu, Li, Liu, Zhuang, Feng, Yao and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Further screening of key targets. (A) Gene Set Enrichment Analysis (GSEA) enrichment of Polo-like kinase1 (PLK1) in cell cycle signaling pathway. NES=2.229, p-value=0, FDR-q-value=0.00213. (B) The Venn diagram is the intersection of key disease targets and drug targets. Purple: key target for triple-negative breast cancer (TNBC) disease, yellow: drug target. We end up with a common gene: PLK1. (C) The protein expression levels of p53 were assayed by Western blot. The expression of PLK1 protein decreased and the expression of p53 increased with the increase of podophyllotoxin in both cell lines.