Table 3.
Co-primary outcomes by task.
| Patient count per task1 | Baseline Mean (SD) | Final visit Mean (SD) | Change Mean (SD) | % Patients improved2 | ||
|---|---|---|---|---|---|---|
| TETRAS Tasks3 | ||||||
| Forward Outstretched | 124 | 2.2 (0.3) | 1.5 (0.6) | –0.6 (0.6)* | 78% | |
| Lateral | 140 | 2.3 (0.4) | 1.7 (0.7) | –0.6 (0.6)* | 80% | |
| Kinetic | 163 | 2.3 (0.4) | 1.7 (0.6) | –0.6 (0.5)* | 79% | |
| Spiral | 161 | 2.5 (0.7) | 2.0 (0.8) | –0.5 (0.8)* | 58% | |
| Handwriting | 144 | 2.8 (0.7) | 2.0 (1.0) | –0.8 (0.8)* | 67% | |
| Dot Approximation | 155 | 2.4 (0.5) | 1.9 (0.7) | –0.4 (0.6)* | 66% | |
| BF-ADL Tasks4 | ||||||
| Use a spoon to drink soup | 196 | 2.9 (0.6) | 2.0 (0.9) | –0.9 (0.8)* | 70% | |
| Hold a cup of tea | 192 | 2.8 (0.7) | 1.8 (0.9) | –1.0 (0.9)* | 71% | |
| Pour milk from a bottle | 182 | 2.8 (0.7) | 1.8 (0.9) | –1.0 (0.9)* | 69% | |
| Dial a telephone | 131 | 2.6 (0.7) | 1.8 (0.9) | –0.8 (0.8)* | 76% | |
| Pick up change | 134 | 2.6 (0.7) | 1.8 (0.9) | –0.8 (0.8)* | 69% | |
| Insert an electric plug | 134 | 2.4 (0.5) | 1.5 (0.6) | –0.9 (0.8)* | 69% | |
| Unlock front door | 148 | 2.4 (0.5) | 1.5 (0.6) | –0.9 (0.8)* | 72% | |
| Write a letter | 192 | 2.3 (0.5) | 1.5 (0.7) | –0.8 (0.8)* | 61% | |
*p ≪ 0.0001 after Holm-Bonferroni corrections for multiple hypothesis testing.
1 Count of patients scoring at least “Mild” per task (2 on TETRAS or BF-ADL).
2 Defined as % patients improving at least one increment (0.5 or 1, depending on scale and task).
3 Each TETRAS task rated 0–4 by clinician (0 = normal, 1 = slight, 2 = mild, 3 = moderate, 4 = severe).
4 Each BF-ADL task rated 1–4 by patient (1 = without difficulty, 2 = with a little effort, 3 = with a lot of effort, 4 = cannot do by yourself).