Table 3.
Test-retest metrics of [18F]FE-PE2I PET measurements (n = 9)
| Region | PET 1 (BPND), COV (%) | PET 2 (BPND), COV (%) | AbsVar (%) | ICC | MDD | Powered detectable % change |
|---|---|---|---|---|---|---|
| Striatum | 1.55 ± 0.33, 21.1 | 1.56 ± 0.32, 20.5 | 5.3 | 0.95 (0.82–0.989) | 0.195 | − 8.3 |
| Caudate | 1.84 ± 0.55, 29.9 | 1.88 ± 0.59, 31.4 | 6.0 | 0.97 (0.89–0.99) | 0.264 | − 8.9 |
| Putamen | 1.26 ± 0.32, 25.3 | 1.25 ± 0.22, 17.8 | 7.5 | 0.91 (0.68–0.98) | 0.225 | − 11.9 |
| Ventral striatum | 2.21 ± 0.53, 23.9 | 2.13 ± 0.38, 17.9 | 6.5 | 0.89 (0.61–0.97) | 0.426 | − 12.1 |
| Substantia nigra | 0.72 ± 0.17, 23.2 | 0.72 ± 0.1, 14.5 | 10.6 | 0.74 (0.24–0.93) | 0.194 | − 17.9 |
COV coefficient of variability (SD/mean × 100), AbsVar absolute variability, ICC intraclass correlation coefficient, MDD minimum detectable difference covering 95% of the distribution of test-retest differences, Powered detectable % change based on measured effect size and power 0.8