Table 4.
List of proteins from the proteomic analysis found to be involved, as an effector or as a regulator, in different cellular pathways: Wnt/β-catenin, AKT, TGF-β and NF-kB.
| Pathway | Protein name | Protein Symbol | p value |
|---|---|---|---|
| Upregulated in rCEnC | |||
| β-catenin83 | Actin-related protein 2/3 complex subunit 3 | ARPC3 | < 0.001 |
| AKT84 | Protein transport protein Sec24C | SEC24C | < 0.005 |
| Downregulated in rCEnC | |||
| β-catenin36 | CDKN2A-interacting protein | CDKN2AIP/CARF | < 0.001 |
| β-catenin35, TGF-β47 | Homeobox protein cut-like 1 | CUX1 | < 0.001 |
| NF-kB85 | DDRGK domain-containing protein 1 | DDRGK1 | < 0.005 |
| TGF-β44,45, β-catenin34 | Endoglin | ENG | < 0.005 |
| β-catenin39 | Protein 4.1 | EPB41/protein 4.1 R | < 0.005 |
| β-catenin39 | Band 4.1-like protein 2 | EPB41L2/protein 4.1 G | < 0.001 |
| β-catenin31,70 | Homeodomain-interacting protein kinase 1 | HIPK1 | < 0.005 |
| β-catenin33 | Integrin beta-5 | ITGB5 | < 0.005 |
| NF-kB86, β-catenin32 | KH domain-containing, RNA-binding, signal transduction-associated protein 1 | KHDRBS1/SAM68 | < 0.005 |
| TGF-β151 | Prolow-density lipoprotein receptor-related protein 1 | LRP1/CD91 | < 0.005 |
| AKT87, TGF-β52 | Pre-B-cell leukaemia transcription factor-interacting protein 1 | PBXIP1/HPIP | < 0.005 |
| TGF-β150 | Paraspeckle component 1 | PSPC1 | < 0.005 |
| AKT88 | Ras-related protein Rab-39A | RAB39A | < 0.001 |
| β-catenin38 | SPARC | SPARC/Osteonectin | < 0.005 |
| β-catenin37 | SPARC-like protein 1 | SPARCL1 | < 0.001 |
| AKT89 | Stromal interaction molecule 1 | STIM1 | < 0.005 |