Table 3.
Multivariate analysis for overall survival
| Variable | Multivariate analysis | ||||
|---|---|---|---|---|---|
| HR (95% CI) | p - value | HR (95% CI) | p - value | ||
| 1st episode (n = 856) | |||||
| Sex | Male | – | – | ||
| Female | – | – | |||
| Age (yrs) | < 60 | – | – | ||
| 60–79 | – | – | |||
| 80+ | 6.208 (2.204, 17.484) | < 0.001 | |||
| All episodes (n = 862) | LNR | LODDS | |||
| Tumour site | Caecum | – | – | ||
| Ascending colon | – | – | |||
| Hepatic flexure | 0.212 (0.046, 0.980) | 0.047 | 0.200 (0.043, 0.922) | 0.039 | |
| Transverse colon | – | – | |||
| Splenic flexure | – | – | |||
| Descending colon | – | – | |||
| Sigmoid colon | 0.092 (0.020, 0.421) | 0.002 | 0.079 (0.017, 0.368) | 0.001 | |
| Rectosigmoid | – | – | |||
| T stage | 0–2 | – | – | ||
| 3 | – | – | |||
| 4 | 8.92 (3.520, 22.605) | < 0.001 | 8.57 (3.394, 21.655) | < 0.001 | |
| N stage | 0 | -* | -* | ||
| 1 | -* | -* | |||
| 2 | -* | -* | |||
| ASA | 1 | -* | -* | ||
| 2 | -* | -* | |||
| 3 | -* | -* | |||
| 4 | -* | -* | |||
| Pathological grade | Undifferentiated | – | – | ||
| Poor differentiation | – | – | |||
| Moderate differentiation | – | – | |||
| Well differentiated | – | – | |||
| LVI | No | – | – | ||
| Yes | – | – | |||
| CRM | Negative > 1 mm | – | – | ||
| Positive ≤1 mm | – | – | |||
| Not reported | – | – | |||
| ≥12 LNY | No | – | – | ||
| Yes | 0.423 (0.220, 0.813) | 0.010 | 0.382 (0.199, 0.734) | 0.004 | |
ASA American Society of Anesthesiologists, CI Confidence interval, CRM Circumferential margin, LNR Lymph node ratio, LNY Lymph node yield, LODDS Log odds of positive lymph nodes, LVI Lymphovascular invasion.
* omitted due to collinearity