Table 1.
Clinical characteristics of IgG4-RD patients
| Parameters | Patients with lung nodules(n = 50) | Patients without lung nodules(n = 39) | P value |
|---|---|---|---|
| Age, median(IQR), years | 60(48–66) | 53(40–72) | 0.30 |
| Men/women, n (%) | 3.55:1(39:11) | 2.25:1(27:12) | 0.35 |
| Smoking history, n (%) | 29(58.0) | 13(33.3) | 0.02* |
| Duration of disease, median(IQR), months | 7(3–12) | 5(2–13) | 0.60 |
| Serum IgG4, median(IQR), mg/dl | 1185(426–2163) | 735(371–2130) | 0.48 |
| Elevated ESR, n (%) | 20(40.0) | 9(23.1) | 0.09 |
| Elevated CRP, n (%) | 9(18.0) | 9(23.1) | 0.55 |
| Reduced C3, n (%) | 23(46.0) | 12(30.8) | 0.14 |
| Reduced C4, n (%) | 16(32.0) | 7(17.9) | 0.13 |
| Positive ANA, n (%) | 20(40.0) | 18(46.2) | 0.56 |
| First symptoms, n (%) | |||
| Salivary gland swelling | 8(16.0) | 3(7.7) | |
| Lymphadenopathy | 6(12.0) | 3(7.7) | |
| Lacrimal gland swelling | 9(18.0) | 8(20.5) | |
| Cough | 7(14.0) | 2(5.1) | |
| Jaundice | 4(8.0) | 2(5.1) | |
| Dysuria | 4(8.0) | 1(2.6) | |
| Fever | 2(4.0) | 7(17.9) | |
| Abdominal pain | 4(8.0) | 8(20.5) | |
| Gum swelling | 1(2.0) | 0 | |
| Low back pain | 2(2.0) | 0 | |
| Edema | 3(6.0) | 3(7.7) | |
| Fatigue | 0 | 1(2.6) | |
| Diarrhea | 0 | 1(2.6) | |
| Number of extrapulmonary organs involved, median(IQR) | 2(1–3) | 2(1–3) | 0.14 |
| Extrapulmonary organ involvement, n (%) | |||
| Salivary glands(submandibular gland and parotid gland) | 21(42.0) | 8(20.5) | |
| Lymph node | 19(38.0) | 15(38.5) | |
| Lacrimal gland | 14(28.0) | 8(20.5) | |
| Pancreas | 15(30.0) | 10(25.6) | |
| Kidney | 16(32.0) | 8(20.5) | |
| Liver | 12(24.0) | 6(15.4) | |
| Nasal sinus | 6(12.0) | 5(12.8) | |
| Skin | 2(4.0) | 2(5.1) | |
| Bile ducts | 4(8.0) | 9(23.1) | |
| Peritoneum | 1(2.0) | 2(5.1) | |
| Pituitary | 1(2.0) | 0 | |
| Thyroid glands | 3(6.0) | 1(2.6) | |
| Gingiva | 1(2.0) | 0 | |
| Pericardium | 1(2.0) | 1(2.6) | |
| Blood | 0 | 2(5.1) | |
Data are expressed as median(interqurtile range) for contious variables, and frequencies(percentages) for categorical variables
IgG4-RD IgG4 related disease, ESR Erythrocyte sedimentation rate, CRP C-reactive protein, C3 Complement 3, C4 Complement 4, ANA Antinuclear antibody, IQR Interquartile range
* P < 0.05