Fig. 1.

HGF alleviated acute lung injury in sepsis. C57BL/6 J mice were randomly assigned to 4 groups. a The HGF treatment schedule, recombinant HGF (1 μg/g) was intravenously administered to the mice via the tail vein immediately and at 12 h after the operation. The mice were sacrificed 24 h after the operation. b Lung histopathological features; c Lung injury score, six random fields in a section from each mouse were photographed and assessed; d Total cell number in the BALF (cells/ml, × 10⁵) was counted by Cell Counter; e, f IL-1β and LDH in the BALF (pg/ml) were measured by ELISA; g, h IL-1β and LDH in the plasma (pg/ml) were measured by ELISA; n = 3, *P < 0.05; (I) Mortality was assessed every 3–4 h, the survival was monitored until 72 h, and the survival curve was analysed, n = 12