Fig. 1.

The illustration of the coordinate system and the 1D scanning results. a The illustration for coordinate of each axis. b Comparison of the one-dimensional pressure field scans of different aberration correction techniques. The measured peak negative pressure (PNP) values corresponding to the central line crossing the targeted point were collected and plotted. The results from transcranial (Skull C) focal pressure scanning without correction with ExAblate- and Kranion-based correction were illustrated. A sonication target was identified at the geometrical center of the therapeutic ultrasound transducer (Target I), and a 10 mm off-centered target was (Target II) used