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. 2020 Aug 14;2:9. doi: 10.1186/s42490-020-00043-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The registration of clinical focused ultrasound system and cadaver skull. a Computer-aided design (CAD) sketch of the clinical transducer, skull fixing frame, and reservoir cover. b Fiducial point-based registration of the transducer elements and skull volume in scanned CT images. Notably, the detailed geometry of the actual FUS transducer was excluded in this study. The sketch in (a) and (b) does not represent the actual scale of the FUS transducer. c Top view illustrating the coordinate configuration, including patient perspective coordinate (patient’s anterior-PA & patient’s posterior-PP, patient’s left-PL & patient’s right-PR), CT image coordinate, and coordinate of hydrophone scanning system (front [F] & back [B], left [L] & right [R])