Table 4.
Selectivity indices of some antitubercular plant species reported in East Africa
| Plant | Solvent | MIC on Mtb strain (μg/ml) | IC50 (μg/ml) | SI | Comment |
|---|---|---|---|---|---|
| Commiphora edulis | Dichloromethane | 1560 | 393 | 0.25 | More toxic to human cells than the Mtb; not useful |
| Ethyl acetate | 3125 | 1734 | 0.55 | More toxic to human cells than the Mtb; not useful | |
| Commiphora ellenbeckii | Water | 780 | 1509 | 1.93 | More toxic to Mtb than human cells but the SI is low. May be optimized for lead candidate identification |
| Methanol | 3125 | 608 | 0.19 | More toxic to human cells than the Mtb; not useful | |
| Commiphora mildbraedii | Methanol | 390 | 452 | 1.16 | More toxic to Mtb than human cells but the SI is close to 1. No practical application |
| Ethyl acetate | 6250 | 339 | 0.054 | More toxic to human cells than the Mtb; not very useful | |
| Khaya senegalensis | Chloroform | 6.25 | 1000 | 160 | More toxic to Mtb than human cells with high SI. Promising for development of lead candidate |
| Rosmarinus officinalis L. | Chloroform | 6.25 | 100 | 16 | More toxic to Mtb than human cells with high SI. Promising for development of lead candidate |
IC50 cytotoxic concentration normal cells, SI selectivity index