Table 1.
Clinical and demographic characteristics of individuals carrying the reference vs. alternate alleles of KIF3A SNPs rs11740584 and rs2299007.
| Clinical variables | rs11740584 Referencea (C) | rs11740584 Alternateb (G) | rs2299007 Referencea (A) | rs2299007 Alternateb (G) |
|---|---|---|---|---|
| N | 27 | 29 | 38 | 18 |
| Black | 4 (15%) | 10 (34%) | 12 (32%) | 2 (11%) |
| Male | 18 (67%) | 19 (66%) | 24 (63%) | 13 (72%) |
| Age | 15.7 ± 4.2 | 14.7 ± 3.4 | 15.3 ± 3.7 | 15.1 ± 4.1 |
| History of AD | 13 (48%) | 15 (52%) | 18 (47%) | 10 (56%) |
| TEWLc | 1.03 (0.87–1.54) | 1.09 (0.85–1.42) | 1.02 (0.86–1.44) | 1.14 (0.80–1.56) |
aReference allele carriers were homozygous for the reference alleles.
bAlternate allele carriers were either heterozygous or homozygous for the alternate alleles.
cTEWL measurements were corrected for day-to-day variation by normalization to the same control subject whose TEWL was measured within 30 min of every subject.