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. 2020 Aug 14;11(8):618. doi: 10.1038/s41419-020-02855-6

Fig. 2. Overexpression of miR-93 attenuates chemoresistance of breast cancer cells via suppressing cell proliferation, inducing G1/S cell cycle arrest, and promoting PTX-induced apoptosis.

Fig. 2

a The cell growth curves were depicted for BCap37, Bats-72, and Bads-200 cells transfected with mimics of NC (NC) or miR-93-5p (miR-93). b, c The colony formation assay was performed in three cell lines with transfection of NC/miR-93. d MiR-93 increased the percentage of G1 phase and reduced the percentage of S phase. e The IC50s of PTX in three cell lines were calculated with transfection of NC/miR-93. f The sensitivity to other first-line anticancer drugs was increased by miR-93 overexpression (BCap37: 5-FU 15 μM, DOX 200 nM, VNB 20 nM; Bats-72: 5-FU 20 μM, DOX 1.5 μM, VNB 200 nM; Bads-200: 5-FU 20 μM, DOX 13 μM, VNB 3 μM). g The apoptosis was evaluated by transfecting NC/miR-93, with or without combinational treatment of PTX. Bars indicate the mean ± SD of three independent replicates. *P < 0.05, **P < 0.01, ***P < 0.001.