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. 2020 Aug 14;11(8):618. doi: 10.1038/s41419-020-02855-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a 210 targets were predicted for miR-93 in four online databases. b The mRNA expression levels of 12 candidate target genes were measured in Bads-200 cells transfected with NC/miR-93. c, d E2F1 and CCND1 were upregulated in tumor samples of breast cancer, by comparing their mRNA levels in clinical tissues (c) and TCGA samples (d). e The dual luciferase assays were performed in Bads-200 cells. f MiR-93 notably downregulated the protein levels of E2F1 and CCND1 in Bads-200 cells, with or without PTX. g Representative images of Bads-200 xenografts with IHC staining of E2F1 and CCND1. Scale bars: (main) 200 μm, (inset) 50 μm. h, i The mRNA and protein levels of E2F1 and CCND1 were measured in BCap37, Bats-72, and Bads-200 cells. Bars indicate the mean ± SD of three independent replicates. *P < 0.05, **P < 0.01, ***P < 0.001.