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. 2020 Aug 14;11(8):618. doi: 10.1038/s41419-020-02855-6

Fig. 5. MiR-93 suppresses cell proliferation and cell cycle progression of breast cancer cells via inhibiting E2F1 and CCND1.

Fig. 5

a, b The cell growth curves were depicted for BCap37 cells with overexpression of E2F1/CCND1 (a), and for Bads-200 cells with knockdown of E2F1/CCND1 (b). c MiR-93 reversed E2F1/CCND1-induced cell cycle promotion. d The pRB/E2F1 activity was increased by overexpression of CCND1 in BCap37 cells, but suppressed by knockdown of CCND1 in Bads-200 cells. e, f The protein levels of several E2F1 targets were measured in BCap37 and Bads-200 cells with specific treatments. Bars indicate the mean ± SD of three independent replicates. *P < 0.05, **P < 0.01, ***P < 0.001.