Fig. 6. MiR-93 promotes apoptosis via repressing E2F1/CCND1 activity and AKT phosphorylation.
a, b The IC50 of PTX was calculated in BCap37 cells overexpressed with E2F1/CCND1 (a), and in Bads-200 cells with E2F1/CCND1 knockdown (b). c, d MiR-93 rescued the E2F1/CCND1-mediated apoptosis reduction in Bads-200 cells. e, f The protein levels of AKT, pAKT, Bcl-2, Bcl-xl, and Bax were measured in BCap37 and Bads-200 cells according to specific treatments. Bars indicate the mean ± SD of three independent replicates. *P < 0.05, **P < 0.01.