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. Author manuscript; available in PMC: 2020 Aug 14.
Published in final edited form as: Nat Chem Biol. 2019 Apr 29;15(6):623–631. doi: 10.1038/s41589-019-0269-7

Figure 1 |. Design, synthesis, and photophysical properties of PhotoSph and PhotoS1P.

Figure 1 |

(A) Design of PhotoSph and PhotoS1P through incorporation of an azobenzene photoswitch into the lipid tail of sphingosine and S1P. (B) Chemical synthesis of PhotoSph and PhotoS1P. (C,D) The UV-Vis spectra of PhotoSph (C) and PhotoS1P (D) in the dark-adapted (black, trans), 365 nm adapted (grey, cis) and 460 nm adapted (blue, trans) photostationary states. Reversible cycling between photoisomers with alternating illumination at 365/460 nm. The experiment was repeated two times with similar results.